TY - CHAP M1 - Book, Section TI - Wound Healing A1 - Nazzal, Munier A1 - Osman, Mohamed F. A1 - Albeshri, Heitham A1 - Abbas, Darren B. A1 - Angel, Carol A. A2 - Brunicardi, F. Charles A2 - Andersen, Dana K. A2 - Billiar, Timothy R. A2 - Dunn, David L. A2 - Kao, Lillian S. A2 - Hunter, John G. A2 - Matthews, Jeffrey B. A2 - Pollock, Raphael E. PY - 2019 T2 - Schwartz's Principles of Surgery, 11e AB - Key PointsWound healing is a complex cellular and biochemical cascade that leads to restitution of integrity and function.All tissues heal by similar mechanisms, and the process undergoes phases of inflammation, cellular migration, proliferation, matrix deposition, and remodeling.Factors that impede normal healing include local, systemic, and technical conditions that the surgeon must take into account.Clinically, excess healing can be as significant a problem as impaired healing; genetic, technical, and local factors play a major role.Optimal outcome of acute wounds relies on complete evaluation of the patient and of the wound and application of best practices and techniques.Antibiotics should be used only in the presence of infection; colonization and contamination does not mean there is infection.Dressing should facilitate the major changes taking place during healing to produce an optimally healed wound and take into consideration the comorbid conditions associated with chronic wounds.Cellular and tissue-based products are additional measures, and these products might accelerate the rate of healing but will not replace basic wound care.Chronic wounds have a decrease in oxygen supply to the wound, which contributes to delayed healing; oxygen therapy might aid in the healing of certain types of wounds.Biofilm is the term used for the bacterial growth on a chronic wound that is encapsulated by a protective layer made up of the host and bacterial proteins; this layer makes it difficult to heal chronic wounds and control infection. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accesssurgery.mhmedical.com/content.aspx?aid=1175969810 ER -