TY  - CHAP
M1  - Book, Section
TI  - Transcervical Thymectomy
A1  - Sihvo, Eero
A1  - Keshavjee, Shaf
A2  - Sugarbaker, David J.
A2  - Bueno, Raphael
A2  - Burt, Bryan M.
A2  - Groth, Shawn S.
A2  - Loor, Gabriel
A2  - Wolf, Andrea S.
A2  - Williams, Marcia
A2  - Adams, Ann
PY  - 2020
T2  - Sugarbaker’s Adult Chest Surgery, 3e
AB  - Myasthenia  gravis  (MG)  is  an  autoimmune  disease  mediated  by  anti–acetylcholine  receptor  (AChr)  antibodies  directed  against  the  AChr  region  of  the  postsynaptic  membrane.  Blocking  and  accelerated  degradation  of  acetylcholine  receptors  lead  to  impaired  neuromuscular  transmission  and  muscle  weakness.1  MG  has  a  predilection  for  the  ocular  and  bulbar  muscles,  but  generalized  proximal  muscle  weakness  is  also  common.  Fatigable  weakness  is  the  hallmark  of  MG,  and  the  disorder  is  diagnosed  by  clinical  presentation,  abnormal  single-fiber  electromyography,  repetitive  nerve  stimulation  tests,  and  elevated  ACh  and/or  anti-MuSK  antibodies.  Abnormalities  of  the  thymus  gland  are  commonly  found  in  these  patients.  Of  MG  patients,  10%  to  15%  have  thymoma.  Lymphoid  thymic  hyperplasia  is  present  in  about  70%.2  Significant  data  support  an  immunopathologic  role  of  the  thymus  in  the  development  of  autoimmune  MG.3  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/25
UR  - accesssurgery.mhmedical.com/content.aspx?aid=1170416296
ER  -