TY - CHAP M1 - Book, Section TI - Adjuvant and Neoadjuvant Chemotherapy A1 - Owen, Dwight H. A1 - Chaft, Jamie E. A2 - Sugarbaker, David J. A2 - Bueno, Raphael A2 - Burt, Bryan M. A2 - Groth, Shawn S. A2 - Loor, Gabriel A2 - Wolf, Andrea S. A2 - Williams, Marcia A2 - Adams, Ann PY - 2020 T2 - Sugarbaker’s Adult Chest Surgery, 3e AB - The only curative intervention for early-stage (I-IIIA) non–small-cell lung cancer (NSCLC) is surgical resection. Yet, despite optimal surgical care, the chance of recurrence and death due to NSCLC is high.1,2 Adjuvant (postoperative) and neoadjuvant (preoperative) treatment with chemotherapy has prolonged survival in select patients with early-stage NSCLC in both prospective trials and systemic meta-analyses. This chapter summarizes the evidence supporting the use of adjuvant and neoadjuvant therapy for patients with early-stage NSCLC. It also highlights the areas where more research is needed and explores ongoing research strategies to optimize both patient and treatment selection to achieve the best outcome for this patient population. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/18 UR - accesssurgery.mhmedical.com/content.aspx?aid=1170411526 ER -