TY - CHAP M1 - Book, Section TI - Role of Surgery in Oligometastatic NSCLC A1 - Gomez, Daniel R. A1 - Heymach, John V. A1 - Swisher, Stephen G. A2 - Sugarbaker, David J. A2 - Bueno, Raphael A2 - Burt, Bryan M. A2 - Groth, Shawn S. A2 - Loor, Gabriel A2 - Wolf, Andrea S. A2 - Williams, Marcia A2 - Adams, Ann PY - 2020 T2 - Sugarbaker’s Adult Chest Surgery, 3e AB - The definition of oligometastatic non–small-cell lung cancer (NSCLC) has historically been based on the number of disease sites. However, this number has varied substantially in the literature, ranging from a solitary metastasis to up to five lesions. In fact, these relatively crude definitions belie a broader biologic state that extends from locally advanced disease to uncontrollable systemic disease burden. The unique state of metastases was proposed by Ralph Weichselbaum and Samuel Hellman in their landmark 1995 review,1 which has since been updated to incorporate more recent supporting data.2 The authors apply the “seed and soil” hypothesis to propose that during the multiple stages of systemic spread, including altered cell adhesion, survival in the circulation, and seeding/propagation in a distant site, any disruption in this process could lead to a more limited metastatic state. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accesssurgery.mhmedical.com/content.aspx?aid=1170410848 ER -