TY - CHAP M1 - Book, Section TI - Chronic Pancreatitis A1 - Baker, Marshall S. A1 - Matthews, Jeffrey B. A2 - Zinner, Michael J. A2 - Ashley, Stanley W. A2 - Hines, O. Joe PY - 2019 T2 - Maingot's Abdominal Operations, 13e AB - Chronic pancreatitis is an inflammatory and fibrosing disease of the exocrine pancreas characterized by irreversible morphological changes and permanent loss of function. The incidence of chronic pancreatitis has increased approximately fourfold over the past several decades. This apparent increase is due in part to a broadening of its definition and the inclusion of patients with earlier-stage disease. The natural history of chronic pancreatitis is unpredictable. Affected individuals typically suffer a pattern of persistent or recurrent attacks of pain and progressive pancreatic exocrine dysfunction. Additional symptoms may develop from extension peripancreatic inflammation and fibrosis to adjacent organs and vascular structures. In later stages, pancreatic endocrine insufficiency may develop. Decision making in the management of chronic pancreatitis must be individualized the specific anatomic and pathological circumstances, taking into account the extent of local expertise in various diagnostic and therapeutic modalities as well as the fact that there is a relative paucity of high-quality data on the clinical effectiveness of surgical and medical interventions. Optimal management is facilitated by a multidisciplinary approach that includes surgical, endoscopic, and radiological expertise in addition to nutrition, endocrinology, pain management, and psychosocial support. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accesssurgery.mhmedical.com/content.aspx?aid=1160045711 ER -