TY - CHAP M1 - Book, Section TI - Metastatic Colorectal Cancer A1 - Lynn, Patricio B. A1 - Keskin, Metin A1 - Garcia-Aguilar, Julio A2 - Morita, Shane Y. A2 - Balch, Charles M. A2 - Klimberg, V. Suzanne A2 - Pawlik, Timothy M. A2 - Posner, Mitchell C. A2 - Tanabe, Kenneth K. PY - 2018 T2 - Textbook of Complex General Surgical Oncology AB - Metastasis is defined as the spread of malignant cells from a primary tumor to a distant organ. It is estimated that 90% of all cancer deaths are a result of metastasis.1 Colorectal cancer (CRC) can metastasize to regional lymph nodes, liver, lung, or the peritoneal surface, and less frequently to other organs such as ovaries, brain, and bone. While CRC with locoregional lymphatic spread is categorized as stage III disease (5-year overall survival (OS) 70.4%), CRC with spread to distant organs is categorized as stage IV—or metastatic—CRC (CRCm) and carries a significantly worse prognosis (5-year OS 12.3%).2 SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/11/10 UR - accesssurgery.mhmedical.com/content.aspx?aid=1145762934 ER -