TY - CHAP M1 - Book, Section TI - Soft Tissue Sarcoma: Epidemiology, Predisposing and Genetic Factors, and Staging A1 - Yoon, Sam S. A1 - Pollock, Raphael E. A2 - Morita, Shane Y. A2 - Balch, Charles M. A2 - Klimberg, V. Suzanne A2 - Pawlik, Timothy M. A2 - Posner, Mitchell C. A2 - Tanabe, Kenneth K. PY - 2018 T2 - Textbook of Complex General Surgical Oncology AB - Soft tissue sarcomas (STS) are comprised of malignant tumors which arise from tissues of mesodermal origin (e.g., fat, muscle, connective tissue, vessels) excluding bone and cartilage. There are over 50 different histologic subtypes of STS.1 In addition, malignant tumors of peripheral nerve sheaths are usually classified at STS despite being ectodermal in origin. Gastrointestinal stromal tumors (GISTs) are derived from the interstitial cells of Cajal, which have neural and smooth muscle features, and thus GISTs are also considered STS.2 The most common subtypes include liposarcoma, leiomyosarcoma, undifferentiated pleomorphic sarcoma (UPS, formerly called malignant fibrous histiocytoma), GIST, and synovial sarcoma. The biological heterogeneity of the different STS subtypes is likely as great as that of all adenocarcinomas (e.g., lung, colorectal, breast, prostate, and other adenocarcinomas), but STS are much less common, and thus they are all grouped together for practical purposes. A subsequent chapter is devoted to the description of the different STS histological subtypes. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accesssurgery.mhmedical.com/content.aspx?aid=1145756508 ER -