TY - CHAP M1 - Book, Section TI - Lung Transplantation and Heart-lung Transplantation A1 - Mallidi, Hari R. A1 - Anand, Jatin A1 - Robbins, Robert C. A2 - Cohn, Lawrence H. A2 - Adams, David H. PY - 2017 T2 - Cardiac Surgery in the Adult, 5e AB - Human lung transplantation, performed as a single lung, double lung, or heart-lung bloc, has emerged as a life-saving procedure for patients with end-stage pulmonary disease. With improvement of operative techniques, organ preservation, and immunosuppressive regimens, combined heart-lung and isolated lung transplantation have become common treatments for patients with a variety of end-stage disease entities. To date, 3703 combined heart-lung transplants and 43,428 lung transplants have been reported worldwide.1 Although the number of heart-lung transplants performed annually has declined in recent years, the number of single-lung transplantation (SLT) procedures remains stable, accompanied by a steady increase in bilateral lung transplant procedures (Fig. 61-1). Clinical progress in thoracic organ transplantation has been considerable, yet significant barriers that limit the scope of these procedures still remain. These include donor organ shortage, limited preservation techniques, graft rejection, and infectious complications. This chapter summarizes the state of the art in combined heart-lung and isolated lung transplantation. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/10/13 UR - accesssurgery.mhmedical.com/content.aspx?aid=1144168471 ER -