TY - CHAP M1 - Book, Section TI - Immunobiology of Heart and Lung Transplantation A1 - Griffith, Bartley P. A1 - Azimzadeh, Agnes A2 - Cohn, Lawrence H. A2 - Adams, David H. PY - 2017 T2 - Cardiac Surgery in the Adult, 5e AB - For over 40 years, cardiac and lung transplantation have achieved remarkable one-year patient survivals beyond 90% and conditional half-lives of 13 and 7.9 years, respectively.1 While surgeons must acquire the technical expertise to perform these often demanding surgeries, long-term graft outcomes and the recipients’ well-being benefit from a multidisciplinary team well versed in the basics of the immunology of transplantation. Comfort with treating patients who receive immunosuppressive therapies, both conventional and innovative, requires familiarity with the nonsurgical language of transplantation. The goal of this enhanced chapter is to squeeze the essentials into an understandable short text. The core features of the alloresponse are presented with some specific references unique to heart and lung allografts. These include (1) histocompatibility; (2) activation of alloresponse T lymphocytes; (3) T-cell–mediated rejection (TMR); (4) antibody-mediated rejection (AMR); (5) immunosuppressive therapy; (6) surveillance for rejection; (7) immune monitoring; and (8) emerging regulators of immunity. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accesssurgery.mhmedical.com/content.aspx?aid=1144168006 ER -