TY - CHAP M1 - Book, Section TI - Sickle Cell Disease A1 - Kato, Gregory J. A1 - Gladwin, Mark T. A2 - Hall, Jesse B. A2 - Schmidt, Gregory A. A2 - Kress, John P. Y1 - 2015 N1 - T2 - Principles of Critical Care, 4e AB - Sickle cell disease causes a chronic hemolytic anemia associated with acute and chronic vaso-occlusion.Baseline hemodynamic and laboratory values in patients with sickle cell disease can be confused with sepsis.Serum creatinine levels of 1 to 1.5 mg/dL often indicate significant renal dysfunction.The most common intensive care management problems in patients with sickle cell disease include the acute chest syndrome, very severe anemia, sepsis, stroke, priapism, splenic sequestration, or right heart failure associated with acute chest syndrome and/or acute severe hemolytic anemia.The acute chest syndrome is a form of acute lung injury that occurs in 10% to 20% of patients hospitalized in vaso-occlusive pain crisis, often caused by fat embolization syndrome or pneumonia.Secondary pulmonary hypertension, defined by right heart catheterization and often unrecognized, occurs in 10% of adult patients with sickle cell disease.Red cell transfusion is an important treatment for most patients with sickle cell disease requiring intensive care management.Rapid exchange transfusion is indicated for central nervous system events, serious respiratory disease, or multiorgan failure.Transfusion management in patients with sickle cell disease requires investigation of alloimmunization history.Preoperative red cell transfusion and detailed supportive care are advisable for significant surgery in patients with sickle cell disease. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accesssurgery.mhmedical.com/content.aspx?aid=1107723217 ER -