TY - CHAP M1 - Book, Section TI - Jaundice, Diarrhea, Obstruction, and Pseudoobstruction A1 - Engels, Paul T. A1 - Tremblay, L. N. A2 - Hall, Jesse B. A2 - Schmidt, Gregory A. A2 - Kress, John P. Y1 - 2015 N1 - T2 - Principles of Critical Care, 4e AB - Jaundice (hyperbilirubinemia) is seen in critically ill patients and can occur due to prehepatic, intrahepatic, or posthepatic causes.Biliary obstruction and acalculous cholecystitis are two common surgical problems requiring urgent intervention.For acalculous or calculous cholecystitis, cholecystectomy removes the inflamed and ischemic gallbladder and prevents recurrence and thus is preferred in those able to tolerate the procedure. A cholecystostomy tube is indicated for nonsurgical candidates.Diarrhea commonly occurs in critical illness (up to 60% of those on enteral feeds) and may be related to infection, medications, malabsorption, composition of the enteral feeds, or gastrointestinal disease.Clostridium difficile should be ruled out as the cause of diarrhea in the ICU or any patient with risk factors (particularly antibiotics or contact) as morbidity and mortality increase with delay in treatment.Fulminant Clostridium difficile can present as an ileus or with diarrhea in a toxic patient, and is associated with high mortality and frequent need for surgical intervention.Studies are ongoing to determine the optimal medical and surgical management of Clostridium difficile. Currently for severe cases enteral vancomycin plus intravenous metronidazole is suggested ± subtotal colectomy or ileostomy with colon lavage.Bowel obstruction should be ruled out prior to managing as pseudoobstruction.Commonest causes of adult small bowel obstruction are adhesions and hernia, whereas commonest causes of adult large bowel obstruction are colon cancer, sigmoid volvulus, and stricture from diverticulitis.Pseudoobstruction (nonmechanical obstruction) is managed by resuscitation, removing or limiting precipitants, using nasogastric or rectal tubes to relieve overdistension, and occasional endoscopic decompression or use of neostigmine in appropriate patients. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accesssurgery.mhmedical.com/content.aspx?aid=1107711666 ER -