TY - CHAP M1 - Book, Section TI - Genomics, Molecular Markers, and Targeted Therapies in Esophageal Cancer A1 - Lin, Jules A1 - Chang, Andrew C. A2 - Sugarbaker, David J. A2 - Bueno, Raphael A2 - Colson, Yolonda L. A2 - Jaklitsch, Michael T. A2 - Krasna, Mark J. A2 - Mentzer, Steven J. A2 - Williams, Marcia A2 - Adams, Ann Y1 - 2015 N1 - T2 - Adult Chest Surgery, 2e AB - Esophageal carcinomas remain a leading cause of cancer-related death worldwide, and the prognosis remains poor with 5-year overall survival of only 17%.1 In the mid-1990s, esophageal adenocarcinoma (EAC) overtook squamous cell carcinoma (ESCC) as the most common esophageal cancer in the United States.2,3 Risk factors include smoking, obesity, and Barrett metaplasia secondary to gastroesophageal reflux, whereas infection with Helicobacter pylori appears to be protective.4 SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accesssurgery.mhmedical.com/content.aspx?aid=1105848078 ER -