TY  - CHAP
M1  - Book, Section
TI  - Sentinel Node Mapping in Lung Cancer
A1  - Colson, Yolonda L.
A1  - Liptay, Michael J.
A1  - Gilmore, Denis
A2  - Sugarbaker, David J.
A2  - Bueno, Raphael
A2  - Colson, Yolonda L.
A2  - Jaklitsch, Michael T.
A2  - Krasna, Mark J.
A2  - Mentzer, Steven J.
A2  - Williams, Marcia
A2  - Adams, Ann
Y1  - 2015
N1  - 
T2  - Adult Chest Surgery, 2e
AB  - Early  in  the  nineteenth  century,  Virchow  implicated  lymph  nodes  in  the  process  of  the  local  spread  of  solid  tumors  to  a  more  widespread  systemic  disease.  The  node  identified  by  Virchow  is  specifically  located  in  the  left  supraclavicular  region.  In  the  modern  vernacular,  the  term  sentinel  lymph  node  (SLN)  describes  the  first  lymph  node  to  receive  drainage  from  any  solid  tumor  in  any  anatomic  region.  It  was  not  until  1989  that  the  concept  of  SLN  biopsy,  as  it  is  currently  known,  was  first  made  popular  based  on  studies  by  Morton  et  al.1  A  feasibility  study  using  blue  dye  was  translated  into  a  successful  clinical  trial  in  patients  with  melanoma.  Their  results  indicated  that  biopsy  and  analysis  of  SLNs  accurately  reflected  the  tumor  status  of  the  lymph  node  basin.  SLN  biopsy  was  introduced  in  breast  cancer  patients  shortly  thereafter.2  Further  studies  supported  SLN  biopsy  as  a  way  to  identify  patients  at  highest  risk  for  locoregional  recurrence  and  metastatic  spread,  and,  therefore,  most  likely  to  benefit  from  adjuvant  therapy.  SLN  mapping  aids  in  the  identification  of  lymph  nodes  at  highest  risk  of  metastasis  and  allows  for  more  detailed  analysis  to  detect  early  metastatic  disease  thus  identifying  patients  who  may  benefit  from  adjuvant  therapy.  While  SLN  biopsy  is  standard  in  both  breast  cancer  and  melanoma  patients,  a  number  of  factors  have  led  to  slower  adoption  in  patients  with  non-small  cell  lung  cancer  (NSCLC).  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/18
UR  - accesssurgery.mhmedical.com/content.aspx?aid=1105848028
ER  -