TY - CHAP M1 - Book, Section TI - Endoscopic Approaches for Treatment of Emphysema A1 - Come, Carolyn E. A1 - Washko, George R. A2 - Sugarbaker, David J. A2 - Bueno, Raphael A2 - Colson, Yolonda L. A2 - Jaklitsch, Michael T. A2 - Krasna, Mark J. A2 - Mentzer, Steven J. A2 - Williams, Marcia A2 - Adams, Ann Y1 - 2015 N1 - T2 - Adult Chest Surgery, 2e AB - Treatment of patients with chronic obstructive pulmonary disease (COPD) traditionally has been the task of the internal medicine physician. Global Initiative for Chronic Obstructive Lung Disease recommendations for treatment of COPD include the use of bronchodilators, anti-inflammatory agents, oxygen therapy, aids to assist with smoking cessation, and pulmonary rehabilitation.1 While pharmacotherapy improves lung function, symptoms, quality of life, and exacerbation rates in COPD, no medical therapies have been shown to improve emphysema, where the primary abnormality is destruction of alveoli with loss of elastic recoil, and subsequent lung hyperinflation. The National Emphysema Treatment Trial (NETT), a large multicenter randomized clinical trial to evaluate the effectiveness of lung volume reduction surgery (LVRS) for the treatment of emphysema, suggested that surgical lung volume reduction, which directly addresses the problem of lung hyperinflation through resection of the most damaged tissue, should be considered for selected patients with emphysema. The findings of this trial, while applicable to a defined subset of COPD patients with advanced upper lobe predominant (ULP) emphysema and reduced exercise capacity, clearly indicate that LVRS can affect lung physiology, symptoms, and even mortality for this disease.2 SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accesssurgery.mhmedical.com/content.aspx?aid=1105844046 ER -