TY - CHAP M1 - Book, Section TI - Molecular and Genomic Surgery A1 - Feng, Xin-Hua A1 - Lin, Xia A1 - Yu, Juehua A1 - Nemunaitis, John A1 - Brunicardi, F. Charles A2 - Brunicardi, F. Charles A2 - Andersen, Dana K. A2 - Billiar, Timothy R. A2 - Dunn, David L. A2 - Hunter, John G. A2 - Matthews, Jeffrey B. A2 - Pollock, Raphael E. Y1 - 2015 N1 - T2 - Schwartz's Principles of Surgery, 10e AB - Biological sciences developed drastically in last 60 years after the uncovering of DNA structure by Watson and CrickThe completion of the human genome sequence in 2003 represents a great milestone in modern science.The technology emerging from molecular and cellular biology has revolutionized the understanding of disease and will radically transform the practice of surgery.The use of genetically modified mouse models and cell lines using gene therapy and RNA interference therapy has greatly contributed to the understanding of the molecular basis for human diseases and targeted therapies.The sequencing of each individual’s genome has the potential to improve the predication, prevention, and targeted treatment of disease, resulting in personalized medicine and surgery.The use of functional genomics and modern molecular analyses will facilitate the discovery of actionable genes to guide choice of care. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accesssurgery.mhmedical.com/content.aspx?aid=1117743393 ER -