TY - CHAP M1 - Book, Section TI - Wound Healing A1 - Barbul, Adrian A1 - Efron, David T. A1 - Kavalukas, Sandra L. A2 - Brunicardi, F. Charles A2 - Andersen, Dana K. A2 - Billiar, Timothy R. A2 - Dunn, David L. A2 - Hunter, John G. A2 - Matthews, Jeffrey B. A2 - Pollock, Raphael E. Y1 - 2015 N1 - T2 - Schwartz's Principles of Surgery, 10e AB - Wound healing is a complex cellular and biochemical cascade that leads to restitution of integrity and function.Although individual tissues may have unique healing characteristics, all tissues heal by similar mechanisms, and the process undergoes phases of inflammation, cellular migration, proliferation, matrix deposition, and remodeling.Factors that impede normal healing include local, systemic, and technical conditions that the surgeon must take into account.Clinically, excess healing can be as significant a problem as impaired healing; genetic, technical, and local factors play a major role.Optimal outcome of acute wounds relies on complete evaluation of the patient and of the wound and application of best practices and techniques. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/10/04 UR - accesssurgery.mhmedical.com/content.aspx?aid=1117741787 ER -