TY - CHAP M1 - Book, Section TI - Neonatal Hypoglycemia A1 - von Allmen, Daniel A2 - Ziegler, Moritz M. A2 - Azizkhan, Richard G. A2 - Allmen, Daniel von A2 - Weber, Thomas R. Y1 - 2014 N1 - T2 - Operative Pediatric Surgery, 2e AB - Hyperinsulinemic hypoglycemia is the common cause of persistent hypoglycemia in the newborn.Mutations in the ABCC8 and KCNJ1 genes are most common and impact the function of the ATP – Potassium Channel in the Beta cell of the islet.Medical therapy includes treatment with continuous feedings, diazoxide and somatostatin analogs.The 2 primary manifestations of the disease are focal and diffuse.Patients with diffuse disease failing medical therapy are treated with 95% pancreatectomy.Patients with focal disease failing medical therapy are treated with complete enucleation of the lesion.Minimally invasive approaches to surgery have been described. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accesssurgery.mhmedical.com/content.aspx?aid=1100438872 ER -