TY - CHAP M1 - Book, Section TI - Melanoma A1 - Doherty, Gerard M. Y1 - 2010 N1 - T2 - Quick Answers Surgery AB - • Predominately a disease of fair-skinned people• Only 15% of melanomas develop in preexisting nevi, the remainder arise de novo• Most important prognostic factors include: -Vertical height of melanoma-Sentinel lymph node status-Number of positive lymph nodes-Presence of metastatic disease• Melanoma typically metastasizes by the lymphatic route in a predictable and orderly fashion• 4 histologic categories of melanoma:-Superficial spreading, 70% of cases-Nodular melanoma, 15% of cases-Lentigo maligna melanoma, 4-10% of cases-Acral lentiginous melanoma, 2-8% of cases• Melanoma most commonly metastasizes to the lungs, liver, and brain but can also involve the bone, adrenals, heart, and bowel SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/28 UR - accesssurgery.mhmedical.com/content.aspx?aid=58094558 ER -