TY - CHAP M1 - Book, Section TI - Colorectal Adenocarcinoma A1 - Doherty, Gerard M. Y1 - 2010 N1 - T2 - Quick Answers Surgery AB - • Colorectal cancer second leading cause of cancer deaths (after lung)• Adenocarcinoma accounts for 95% of malignant colorectal tumors• Genetic predisposition in familial adenomatous polyposis and hereditary nonpolyposis colorectal cancer (HNPCC)• Conditions predisposing to colorectal cancer -Ulcerative colitis-Crohn colitis-Schistosomal colitis-Exposure to radiation-Presence of ureterocolostomy• Possible dietary influences-High caloric intake-High saturated fat intake-Decreased dietary calcium-Decreased fiber intake• Carcinogenesis multi-step process involving dysfunction of tumor suppressor genes, including APC, DCC, P53• Distribution of colorectal cancer-25% right colon-10% transverse colon-15% left colon-20-50% rectosigmoid colon• Spreads through direct extension, hematogenously, lymph nodes, transperitoneal, intraluminal• Synchronous lesions occur in 3-5% SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/29 UR - accesssurgery.mhmedical.com/content.aspx?aid=58107898 ER -