TY - CHAP M1 - Book, Section TI - Cerebrovascular Disease, Atherosclerotic A1 - Doherty, Gerard M. Y1 - 2010 N1 - T2 - Quick Answers Surgery AB - • Symptoms more often result from emboli than hypoperfusion• 80% of patients with occlusive cerebrovascular disease have accessible arterial lesion in neck/chest• When blood supply decreases below critical level, cellular death occurs in minutes• Embolization most common mechanism of stroke from carotid lesions• Most strokes due to lesions of internal carotid but can be from innominate/ aorta• Low wall shear stress, flow separation, loss of unidirectional flow may lead to atherosclerosis in carotid bulb• Neurologic dysfunction without infarction can be produced in 2 ways:1. Cerebral embolization by microembolic fragments2. Transient reduction in cerebral perfusion• Antiplatelet therapy decreases stroke rates by 5% SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/29 UR - accesssurgery.mhmedical.com/content.aspx?aid=58106568 ER -