TY  - CHAP
M1  - Book, Section
TI  - Chapter 21. Multiple Endocrine Neoplasia Type 1
A1  - Whaley, J. Greg
A1  - Lairmore, Terry C.
A2  - Morita, Shane Y.
A2  - Dackiw, Alan P. B.
A2  - Zeiger, Martha A.
Y1  - 2010
N1  - 
T2  - McGraw-Hill Manual: Endocrine Surgery
AB  - Multiple  endocrine  neoplasia  type  1  (MEN1)  is  an  autosomal  dominant  genetic  predisposition  to  develop  multiglandular  parathyroid  disease,  benign  and  malignant  neuroendocrine  tumors  (NET  of  the  pancreas  and  duodenum,  and  adenomas  of  the  anterior  pituitary.1,2  Benign  and  malignant  tumors  of  these  organs  may  develop,  with  multiple  target  organs  affected  and  multifocal  tumors  within  a  target  organ.  Less  often,  carcinoid  tumors  (bronchial,  gastrointestinal,  or  thymic),  lipomas,  cutaneous  angiofibromas,  or  ependymomas  of  the  central  nervous  system  may  be  associated  with  this  syndrome.  The  clinical  definition  of  MEN1  includes  a  patient  with  tumor  development  in  two  associated  endocrine  tissues  (parathyroid,  pancreas,  pituitary)  and  a  first-degree  relative  with  involvement  of  one  of  the  three  principal  endocrine  tissues.  Direct  genetic  testing  can  detect  disease-associated  germline  mutations  in  the  MEN1  gene  and  identify  affected  individuals.  
SN  - 
PB  - The McGraw-Hill Companies
CY  - New York, NY
Y2  - 2024/04/20
UR  - accesssurgery.mhmedical.com/content.aspx?aid=6163914
ER  -