TY - CHAP M1 - Book, Section TI - Chapter 5. Follicular Thyroid Carcinoma and Oncocytic (Hürthle Cell) Carcinoma A1 - Yip, Linwah A1 - Carty, Sally E. A2 - Morita, Shane Y. A2 - Dackiw, Alan P. B. A2 - Zeiger, Martha A. Y1 - 2010 N1 - T2 - McGraw-Hill Manual: Endocrine Surgery AB - A normal human thyroid gland contains 20 to 30 million spherical follicles lined with follicular epithelial cells filled with colloid and stores a 3 months' supply of thyroid hormone.1 Among the several differentiated thyroid cancers that originate from thyroid follicular cells, 10% to 15% are follicular thyroid carcinomas (FTCs) and 3% to 5% are oncocytic (Hürthle) cell carcinomas (HCCs).2 Recent studies suggest that FTC may represent only 5% of differentiated thyroid cancer in geographical regions with well-supplemented iodine diets. In iodine-deficient regions, however, FTC may account for up to 25% to 40% of thyroid carcinomas.3 In contrast, HCC may be more common in areas with iodine-rich diets.4 The mean age at presentation is higher for HCC (55 years) than for FTC (48 years). In most reports, both disorders are approximately twofold more common in women than men.5 SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/04/19 UR - accesssurgery.mhmedical.com/content.aspx?aid=6162389 ER -