TY - CHAP M1 - Book, Section TI - Chapter 83. Selection of Patients for Therapy A1 - Irvin Jr, William A1 - Amos, Keith A2 - Kuerer, Henry M. Y1 - 2010 N1 - T2 - Kuerer's Breast Surgical Oncology AB - Initial observational studies of the natural history of breast cancer (untreated) viewed all breast cancers as the same, causing death a median of 2.7 years after presentation.1 Similarly, initial treatment trials2-4 viewed breast cancer as a homogeneous disease with no consideration of possible biological differences. Fortunately, in the 1960s, breast cancer heterogeneity was beginning to be recognized and included such factors as tumor size, the number of tumor-involved lymph nodes,5-7 and later the influence of estrogen receptor (ER) and progesterone receptor (PR).8-10 SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/29 UR - accesssurgery.mhmedical.com/content.aspx?aid=6416696 ER -