TY - CHAP M1 - Book, Section TI - Chapter 45. Percutaneous Catheter-Based Mitral Valve Repair A1 - Mack, Michael J. A2 - Cohn, Lawrence H. Y1 - 2012 N1 - T2 - Cardiac Surgery in the Adult, 4e AB - There has been intense interest over the past decade in developing percutaneous catheter-based techniques to manage valvular heart disease.1–4 Although the success has been rapid to the point of being disruptive in catheter treatment of aortic stenosis, progress has been much more modest in correcting mitral regurgitation (MR) percutaneously.5 The success of catheter-based treatment of aortic stenosis can be attributed to a singular pathophysiology of the disease and the successful development of delivery systems and techniques to treat this disorder using conventional imaging techniques. The field of percutaneous mitral valve repair, however, has not progressed nearly as rapidly for a host of reasons. These include the complex pathophysiology of MR with diverse causes as well as challenging imaging and complex delivery issues. These obstacles have led to slower than anticipated clinical adoption of catheter-based approaches for the treatment of MR. To understand the potential for successful therapy, it is first instructive to examine the pathophysiology of the various mechanisms of the disease. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/04/19 UR - accesssurgery.mhmedical.com/content.aspx?aid=55924037 ER -