TY - CHAP M1 - Book, Section TI - Musculoskeletal Oncology A1 - Bernthal, Nicholas M. A1 - Burke, Zachary D.C. A1 - Blumstein, Gideon W. A1 - Greig, Danielle A1 - Shah, Akash A2 - McMahon, Patrick J. A2 - Skinner, Harry B. Y1 - 2021 N1 - T2 - Current Diagnosis & Treatment in Orthopedics, 6e AB - Musculoskeletal oncology is a field of medicine that involves the diagnosis and management of neoplastic conditions affecting the musculoskeletal system. This not only entails neoplasia of mesenchymal origin (derived from embryonic mesoderm), but also metastatic carcinoma and a variety of pseudotumorous conditions. Mesenchymal tumors are an extremely heterogeneous group of neoplasms including over 200 benign conditions and 90 types of sarcoma. The majority of this chapter is dedicated to these conditions. The relative incidence of benign to malignant disease is 200:1. These tumors are classified histomorphologically based on features of differentiation, but there is considerable overlap. It is reasonable to consider these separate conditions as points on a continuum, rather than entirely distinct entities. Classification, nevertheless, is important because it may yield insight to the behavior, treatment response, and overall prognosis. Benign disease, by definition, exhibits little tendency to locally recur or metastasize, and is generally not aggressive in terms of local tissue destruction. However, some benign lesions are more likely to exhibit aggressive growth than others, and several lesions traditionally described as benign have relatively high rates of local recurrence and the potential to metastasize. Sarcomas (malignant tumors of mesenchymal origin) are often rapidly destructive, have metastatic potential, and have a tendency to locally recur. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accesssurgery.mhmedical.com/content.aspx?aid=1181617562 ER -