TY - CHAP M1 - Book, Section TI - Vaccinations A1 - Weinstein, Jay A1 - Reimundes, Ezequiel Rodríguez A1 - Enríquez, Natalia Beatriz A2 - Molmenti, Ernesto Pompeo A2 - Santibañes, Martin de A2 - Santibañes, Eduardo de Y1 - 2021 N1 - T2 - Liver Transplantation: Operative Techniques and Medical Management AB - Infectious diseases are a major cause of morbidity and mortality in patients with chronic liver disease, both before and after liver transplantation. Impaired humoral and cellular immunity in these patients is attributable to liver disease itself but also to immunosuppressive agents.1–10 Active immunization is an effective way to protect transplant recipients against certain infectious agents. Patients should be immunized against common infections such as pneumococci and influenza as soon as chronic liver disease is diagnosed.11–14 Vaccination against hepatitis A and B virus is also recommended for these patients who are vulnerable to viral coinfection. Furthermore, infections can contribute to rejection of the transplanted organ and to the subsequent development of certain types of cancers. Following transplantation, the risk for infectious diseases increases and the serologic response to vaccination decreases due to immunosuppressive agents. For this reason, efforts should be made to vaccinate patients early in the course of liver disease. SN - PB - McGraw Hill CY - New York, NY Y2 - 2024/10/15 UR - accesssurgery.mhmedical.com/content.aspx?aid=1180108572 ER -