TY - CHAP M1 - Book, Section TI - Acute Liver Failure A1 - D’Agostino, Daniel E. A1 - Sanchez, Maria C. A1 - del Pont, Jose Marco A1 - Wander, Praneet A1 - Maliakkal, Benedict A1 - Satapathy, Sanjaya K. A1 - Maliakkal, Benedict A1 - Abdul Khan, Mubeen Mohammed A1 - Satapathy, Sanjaya K. A2 - Molmenti, Ernesto Pompeo A2 - Santibañes, Martin de A2 - Santibañes, Eduardo de Y1 - 2021 N1 - T2 - Liver Transplantation: Operative Techniques and Medical Management AB - Acute liver failure (ALF) is a devastating illness in a previously healthy child. The mortality rate may reach 80% to 90% in the absence of liver transplant. In some pediatric series, survival rates of 50% to 75% have been reported. Pediatric ALF is defined as a hepatic-based coagulopathy that is not corrected by parenteral administration of vitamin K; lack of evidence of chronic liver disease; and prothrombin time (PT) ≥20 seconds; or international normalized ratio (INR) ≥2, based on the consensus of the Pediatric Acute Liver Failure (PALF) Study Group. SN - PB - McGraw Hill CY - New York, NY Y2 - 2024/04/19 UR - accesssurgery.mhmedical.com/content.aspx?aid=1180107102 ER -