TY - CHAP M1 - Book, Section TI - Chronic Kidney Disease and Renal Replacement Therapy A1 - Lee, Brian K. A1 - Vincenti, Flavio G. A2 - McAninch, Jack W. A2 - Lue, Tom F. Y1 - 2020 N1 - T2 - Smith & Tanagho's General Urology, 19e AB - In chronic kidney disease (CKD), reduced clearance of certain solutes principally excreted by the kidney results in their retention in the body fluids. The solutes are end products of endogenous metabolism as well as exogenous substances (eg, drugs). The most commonly measured indicators of renal failure are blood urea nitrogen (BUN) and serum creatinine. The renal clearance of creatinine (as calculated from a 24-hour urine collection) is often used as a surrogate measure of glomerular filtration rate (GFR). SN - PB - McGraw Hill CY - New York, NY Y2 - 2024/04/18 UR - accesssurgery.mhmedical.com/content.aspx?aid=1171185610 ER -