TY - CHAP M1 - Book, Section TI - Immunotherapy for Mesothelioma A1 - Tano, Zachary E. A1 - Dozier, Jordan A1 - Vaghjiani, Raj G. A1 - Adusumilli, Prasad S. A2 - Sugarbaker, David J. A2 - Bueno, Raphael A2 - Burt, Bryan M. A2 - Groth, Shawn S. A2 - Loor, Gabriel A2 - Wolf, Andrea S. A2 - Williams, Marcia A2 - Adams, Ann Y1 - 2020 N1 - T2 - Sugarbaker’s Adult Chest Surgery, 3e AB - Utilizing the body’s own immune responses to combat malignancies is not a recent phenomenon. In the late 1880s, Dr. William B. Coley utilized staphylococcal toxins following his observation of tumor regression in patients who had been exposed to infectious pathogens.1 In recent years, the application of immunotherapy has evolved to include many different biologic facets such as modulating the tumor immune microenvironment (TME) and shifting its balance toward an antitumor state (Fig. 121-1). Current immunotherapeutic treatments for malignant pleural mesothelioma (MPM) involve cell- and antibody-mediated immunotherapies. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/20 UR - accesssurgery.mhmedical.com/content.aspx?aid=1170414092 ER -