TY - CHAP M1 - Book, Section TI - Endoscopic Techniques in Antireflux Surgery A1 - Rodríguez, María A1 - Wee, Jon O. A2 - Sugarbaker, David J. A2 - Bueno, Raphael A2 - Burt, Bryan M. A2 - Groth, Shawn S. A2 - Loor, Gabriel A2 - Wolf, Andrea S. A2 - Williams, Marcia A2 - Adams, Ann Y1 - 2020 N1 - T2 - Sugarbaker’s Adult Chest Surgery, 3e AB - Gastroesophageal reflux disease (GERD) is one of the most prevalent diseases that we meet in daily practice, and its prevalence continues to rise.1,2 If left untreated or improperly managed, GERD can lead to esophagitis, esophageal strictures, aspiration, pneumonia, vocal cold inflammation and subsequent hoarseness, pulmonary dysfunction, Barrett esophagus, and esophageal cancer.2 Proton pump inhibitors (PPIs) have been for many years the principal medical treatment of GERD, but unfortunately between 20% and 30% of patients with erosive esophagitis and up to 40% of patients with nonerosive GERD have no or limited response to PPIs, even when their dose is doubled.3 There is also the concern for potential adverse effects of long-term treatment with PPIs including Clostridium difficile infection, bone fractures, hypomagnesemia and higher incidence of chronic kidney disease in susceptible individuals.4–6 SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accesssurgery.mhmedical.com/content.aspx?aid=1170408114 ER -