TY - CHAP M1 - Book, Section TI - Perspective on Management of Patients with Acute Pancreatitis A1 - Bouwense, Stefan A.W. A1 - van Santvoort, Hjalmar C. A1 - Besselink, Marc G.H. A2 - Zinner, Michael J. A2 - Ashley, Stanley W. A2 - Hines, O. Joe Y1 - 2019 N1 - T2 - Maingot's Abdominal Operations, 13e AB - Acute pancreatitis is the most common gastrointestinal disease for which patients are acutely hospitalized, and its incidence continues to rise.1 The majority of patients (approximately 80%) with acute pancreatitis have mild disease, and symptoms usually resolve within 1 week with basic supportive care.2,3 The other 20% of patients develop a severe form of pancreatitis with organ failure and necrotizing pancreatitis. Necrotizing pancreatitis is now defined as either pancreatic parenchymal necrosis and peripancreatic fat necrosis or peripancreatic fat necrosis alone.2,4 The clinical course of these patients is often characterized by a persisting systemic inflammatory response syndrome and/or (multiple) organ failure for the first 1 to 2 weeks. Despite maximal supportive care in the intensive care unit, mortality is up to 30% in patients with early persisting organ failure.5,6 Secondary infection of the necrosis develops in 30% of patients and carries a mortality risk of approximately 15%.7,8 SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accesssurgery.mhmedical.com/content.aspx?aid=1160045604 ER -