TY - CHAP M1 - Book, Section TI - Transthoracic Esophagectomy A1 - Kawakubo, Hirofumi A1 - Takeuchi, Hiroya A1 - Kitagawa, Yuko A2 - Morita, Shane Y. A2 - Balch, Charles M. A2 - Klimberg, V. Suzanne A2 - Pawlik, Timothy M. A2 - Posner, Mitchell C. A2 - Tanabe, Kenneth K. Y1 - 2018 N1 - T2 - Textbook of Complex General Surgical Oncology AB - Multimodality approaches including surgery, radiotherapy, and chemotherapy are essential for the treatment of advanced esophageal carcinoma.1,2 Surgery has been used for locoregional control and has played a major role in the treatment of midstage esophageal cancer.3 The tumor site is an important factor in the selection of surgical approaches because the distribution and incidence of lymph node metastasis vary according to the location of primary tumors. Moreover, the midthoracic esophagus is the most frequent site of primary tumors of thoracic esophageal squamous cell carcinoma (SCC), whereas adenocarcinomas (ADC) are usually located in the lower thoracic esophagus or esophagogastric junction.4 Thoracic esophageal SCC are commonly accompanied by extensive lymph node metastases from cervical to abdominal regions. Although cervical and upper mediastinal nodes are more commonly involved in patients with carcinomas of the upper thoracic esophagus, lower mediastinal and perigastric nodes are the most common sites in patients with carcinomas of the lower thoracic esophagus.5 In patients with carcinomas of the middle thoracic esophagus, the primary lesion is often accompanied by extensive metastases in lymph nodes located from the neck to the abdomen. Thus, transthoracic esophagectomy and mediastinal lymph node dissection are generally performed as a curative surgical resection. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accesssurgery.mhmedical.com/content.aspx?aid=1145761028 ER -