TY - CHAP M1 - Book, Section TI - Genetic and Familial Syndromes A1 - Euhus, David A2 - Morita, Shane Y. A2 - Balch, Charles M. A2 - Klimberg, V. Suzanne A2 - Pawlik, Timothy M. A2 - Posner, Mitchell C. A2 - Tanabe, Kenneth K. Y1 - 2018 N1 - T2 - Textbook of Complex General Surgical Oncology AB - Genetic predisposition accounts for only a fraction of breast cancers, but genetic testing, in the appropriate context, is the most powerful tool available for quantitative risk stratification. The information provided by genetic testing contributes directly to risk management decisions and, frequently, to decisions about cancer treatment. BRCA1 and BRCA2 are still responsible for the majority of hereditary breast cancer cases, but the list of rare genes is increasing rapidly. The commercialization of massive parallel sequencing tests (i.e., next generation sequencing) has revolutionized genetic testing. Panel testing is becoming more common and patients are presenting more frequently with rare mutations in genes like CHEK2, PALB2, and ATM. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accesssurgery.mhmedical.com/content.aspx?aid=1145759910 ER -