TY - CHAP M1 - Book, Section TI - Ectopic ACTH Syndrome A1 - Goff, Stephanie L. A1 - Hughes, Marybeth S. A2 - Morita, Shane Y. A2 - Balch, Charles M. A2 - Klimberg, V. Suzanne A2 - Pawlik, Timothy M. A2 - Posner, Mitchell C. A2 - Tanabe, Kenneth K. Y1 - 2018 N1 - T2 - Textbook of Complex General Surgical Oncology AB - Cushing’s syndrome is a symptomatic manifestation of a wide variety of disease processes culminating in hypercortisolism, only a few of which, including ectopic ACTH syndrome (EAS), necessitate the attention of a surgical oncologist.1 In the classical setting of EAS, the diagnosis begins under the supervision of an endocrinologist, and the careful application of a diagnostic algorithm of laboratory testing, imaging, and/or interventional procedures often helps identify a source.2 However, EAS can also present in a paraneoplastic fashion in a patient with a known malignancy, and surgical oncologists may be called upon to identify a potential source. This chapter will briefly review the physiology of the hypothalamic-pituitary-adrenal (HPA) axis and Cushing’s syndrome, discuss the diagnosis of EAS and its descriptive classifiers, and outline management strategies for the care of patients with EAS. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accesssurgery.mhmedical.com/content.aspx?aid=1145758546 ER -