TY - CHAP M1 - Book, Section TI - Medullary Thyroid Cancer A1 - Yip, Linwah A1 - Stang, Michael T. A1 - McCoy, Kelly L. A1 - Carty, Sally E. A2 - Morita, Shane Y. A2 - Balch, Charles M. A2 - Klimberg, V. Suzanne A2 - Pawlik, Timothy M. A2 - Posner, Mitchell C. A2 - Tanabe, Kenneth K. Y1 - 2018 N1 - T2 - Textbook of Complex General Surgical Oncology AB - Medullary thyroid cancer (MTC) is a well-differentiated neuroendocrine tumor arising from the calcitonin-producing parafollicular cells, also known as C cells. C cells are derived from neural crest cells that form the ultimobranchial bodies of the fourth and fifth branchial pouches. During thyrogenesis, the ultimobranchial bodies fuse with the thyroid laterally and as a result, C cells are concentrated in the upper poles of the thyroid. In addition to calcitonin, MTC may secrete carcinoembryonic antigen (CEA), adrenocorticotrophic hormone (ACTH), and occasionally somatostatin. Symptoms related to hormone hypersecretion such as diarrhea, flushing, or Cushing’s syndrome may be the presenting manifestation and are usually representative of advanced disease. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accesssurgery.mhmedical.com/content.aspx?aid=1145757471 ER -