TY - CHAP M1 - Book, Section TI - Desmoid Tumors A1 - Rosenberg, Laura M. A1 - Hull, Melissa A. A1 - Mullen, John T. A2 - Morita, Shane Y. A2 - Balch, Charles M. A2 - Klimberg, V. Suzanne A2 - Pawlik, Timothy M. A2 - Posner, Mitchell C. A2 - Tanabe, Kenneth K. Y1 - 2018 N1 - T2 - Textbook of Complex General Surgical Oncology AB - Desmoid tumors are fibrous mesenchymal neoplasms that arise from deep musculoaponeurotic structures. They may occur sporadically or in association with familial adenomatous polyposis (FAP). Though desmoid tumors lack the ability to metastasize, they are locally invasive, often behaving clinically like low-grade fibrosarcomas. This local tissue destruction can lead to significant morbidity, disfigurement, functional deficit, and death. Desmoid tumors have an unpredictable natural history, with some exhibiting the ability to grow rapidly to large size, while other tumors may remain stable for years, and still others may regress completely without treatment. They have a propensity to recur despite complete surgical resection. Treatment consists of surgery, radiation therapy (RT), and systemic therapies, in varying combinations. The rarity of desmoid tumors, combined with their highly variable clinical course, has made formulating consensus guidelines for treatmentdifficult, and considerable controversy still exists regarding many aspects of management. This chapter will provide an overview of the clinicopathologic features of desmoid tumors and will address the diversity of options available in their treatment. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accesssurgery.mhmedical.com/content.aspx?aid=1145756889 ER -