TY - CHAP M1 - Book, Section TI - Radiation Therapy for Metastatic Melanoma A1 - Hong, Angela M. A1 - Fogarty, Gerald B. A2 - Morita, Shane Y. A2 - Balch, Charles M. A2 - Klimberg, V. Suzanne A2 - Pawlik, Timothy M. A2 - Posner, Mitchell C. A2 - Tanabe, Kenneth K. Y1 - 2018 N1 - T2 - Textbook of Complex General Surgical Oncology AB - Radiation therapy (RT) in patients with metastatic melanoma in regional lymph nodes may be used as adjuvant treatment, or occasionally as definitive treatment, when surgery is not feasible or contraindicated. The rationale for adjuvant RT in patients with stage III melanoma is to reduce the risk of regional node field recurrence, which can cause significant morbidity and seriously reduce quality of life. The notion that melanoma rarely responds to RT has been dispelled by a recent randomized study in patients with AJCC stage III melanoma that demonstrated a significant reduction in node field recurrence with the addition of adjuvant RT.1 Whether improved regional control improves survival remains speculative. However, metastasis to a regional node field undoubtedly indicates an increased risk of distant metastasis, with a progressive reduction in survival associated with increasing tumor burden in the node field.2 SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accesssurgery.mhmedical.com/content.aspx?aid=1145756081 ER -