TY  - CHAP
M1  - Book, Section
TI  - Radical En Bloc Esophagectomy
A1  - Lee, Paul C.
A1  - Altorki, Nasser K.
A2  - Sugarbaker, David J.
A2  - Bueno, Raphael
A2  - Colson, Yolonda L.
A2  - Jaklitsch, Michael T.
A2  - Krasna, Mark J.
A2  - Mentzer, Steven J.
A2  - Williams, Marcia
A2  - Adams, Ann
PY  - 2015
T2  - Adult Chest Surgery, 2e
AB  - Despite  improvements  in  perioperative  care,  surgical  techniques,  and  neoadjuvant  therapy  over  the  last  decade,  the  prognosis  of  esophageal  cancer  remains  poor.  More  than  95%  of  new  cases  diagnosed  annually  in  the  United  States  succumb  to  disease.  Among  the  subset  of  patients  resected  with  curative  intent  (R0  resection),  the  5-year  survival  after  transthoracic  esophagectomy  or  transhiatal  esophagectomy  rarely  exceeds  30%  based  on  reports  from  large  surgical  series.1-4  The  principal  justification  for  these  poor  results  is  the  finding  that  most  patients  develop  metastatic  disease  and  already  may  have  disseminated  disease  at  the  time  of  diagnosis.  A  careful  analysis  of  the  patterns  of  failure  after  surgical  resection  also  implicates  inadequate  locoregional  control.  The  locoregional  failure  rates  are  unacceptably  high  after  conventional  surgical  resection,  ranging  from  30%  to  60%.5-8  The  addition  of  preoperative  therapy  of  any  kind  does  not  meaningfully  reduce  the  high  rate  of  local  failure.6-8  Thus  a  meaningful  improvement  in  the  survival  of  patients  with  esophageal  cancer  is  unlikely  without  adequate  locoregional  control.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/20
UR  - accesssurgery.mhmedical.com/content.aspx?aid=1105838881
ER  -