TY - CHAP M1 - Book, Section TI - Esophageal Cancer A1 - Lin, Jules A1 - Orringer, Mark B. A2 - Yuh, David D. A2 - Vricella, Luca A. A2 - Yang, Stephen C. A2 - Doty, John R. PY - 2014 T2 - Johns Hopkins Textbook of Cardiothoracic Surgery AB - EpidemiologyEsophageal adenocarcinoma is the fastest growing solid malignancy in the United States.PathophysiologyBarrett metaplasia is the precursor lesion to esophageal adenocarcinoma.Clinical featureMost patients presenting with symptoms already have systemic disease.DiagnosticIn selecting the optimal treatment, endoscopic ultrasound is an important tool in determining the depth of invasion and regional nodal involvement.TreatmentNeoadjuvant chemoradiation may improve survival particularly in patients with a complete pathologic response.PrognosisThe stage at diagnosis is the most important prognostic factor. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/20 UR - accesssurgery.mhmedical.com/content.aspx?aid=1104586582 ER -