TY - CHAP M1 - Book, Section TI - Intestine Transplantation A1 - Reyes, Jorge A2 - Ziegler, Moritz M. A2 - Azizkhan, Richard G. A2 - Allmen, Daniel von A2 - Weber, Thomas R. PY - 2014 T2 - Operative Pediatric Surgery, 2e AB - Isolated intestinal transplantation is indicated for patients with permanent intestinal failure whose liver, including portal pressures and other systemic organs are normal. Outcomes are very good with 1-year patient and graft survivals approaching 90% and 80%, respectively.Combined intestine–liver transplantation is indicated if intestinal failure is accompanied by end-stage liver disease or severe portal hypertension (cholestasis, hypersplenism, coagulopathy). Outcomes remain favorable with about a 70% patient and graft 1-year survivals.A discouraging and as yet unexplained outcome is the fall-off of patient and graft survival at 10 years for both isolated intestine as well as intestine–liver transplants.The progressive development of newer improved immunosuppressive strategies has diminished the frequency of organ rejection and graft versus host disease which may lower long-term complication rates such as vascular, gastrointestinal, infectious, and lymphoproliferative disorders. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accesssurgery.mhmedical.com/content.aspx?aid=1100431786 ER -