TY  - CHAP
M1  - Book, Section
TI  - Chronic Pancreatitis in the Pediatric Population
A1  - Bondoc, Alex
A1  - Tiao, Greg M.
A2  - Ziegler, Moritz M.
A2  - Azizkhan, Richard G.
A2  - Allmen, Daniel von
A2  - Weber, Thomas R.
PY  - 2014
T2  - Operative Pediatric Surgery, 2e
AB  - An  unremitting,  deranged  inflammatory  response  characterizes  chronic  pancreatitis  (CP)  in  children  and  is  modulated  by  environmental  and  genetic  factors.Unlike  adults,  the  etiology  of  pediatric  CP  involves  congenital  or  anatomic  variants,  genetic  mutations,  or  autoimmune  disease.The  diagnostic  work-up  of  children  suspected  to  have  CP  should  include  sweat  chloride  assessment,  genetic  assay  for  CFTR,  SPINK1,  and  PRSS  mutations,  endoscopic  and/or  radiographic  imaging,  and  autoimmune  testing.Initial  therapy  for  CP  includes  treatment  for  symptoms  including  pain  and  endocrine  and/or  exocrine  insufficiency.  However,  more  invasive  endoscopic  or  surgical  therapy  may  be  necessary  and  is  often  predicated  on  degrees  of  ductal  obstruction  and  parenchymal  disease.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/19
UR  - accesssurgery.mhmedical.com/content.aspx?aid=1100952828
ER  -