TY - CHAP M1 - Book, Section TI - Non-Hodgkin Lymphoma A1 - Doherty, Gerard M. PY - 2010 T2 - Quick Answers Surgery AB - • The diagnosis of non-Hodgkin lymphoma encompasses a wide spectrum of lymphoid-derived tumors• More than 10 distinct tumor subtypes with variable biologic behavior• Non-Hodgkin lymphoma may originate from B cells, T cells, or histiocytes• In contrast to Hodgkin lymphoma, lymph node tumor involvement is more likely to spread in a noncontinous fashion in non-Hodgkin lymphoma• Prognosis and treatment is more dependent on the grade and type of malignancy in contrast to the importance of clinical stage in Hodgkin lymphoma• Functionally separated into low-grade and high-grade groups• 33% of cases arise outside of the lymph nodes: oropharynx, paranasal sinuses, thyroid, GI tract, liver, testicles, skin, bone marrow, and CNS• Most common extranodal site is the stomach, accounting for 50% of all GI lymphomas• Most accepted classification system is the Revised European-American Lymphoma (REAL) classification SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/11/06 UR - accesssurgery.mhmedical.com/content.aspx?aid=58095608 ER -