TY - CHAP M1 - Book, Section TI - Cystic Fibrosis A1 - Doherty, Gerard M. PY - 2010 T2 - Quick Answers Surgery AB - • Serious congenital disorder, autosomal recessive disorder• Most common mutation is deletion of amino acid in position 508 (Phe)• Defect in chloride transport, results in more NaCl absorption in the airway• Defect occurs in apocrine sweat glands tracheobronchial tree, pancreas, GI tract• Airway secretions are low in volume and high in viscosity• Mucoid plugs form and are rubbery, semisolid, gray to greenish yellow in color resulting in impaction• Often history of recurrent upper respiratory tract infection, fever, and chest pain SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/29 UR - accesssurgery.mhmedical.com/content.aspx?aid=58108522 ER -