TY - CHAP M1 - Book, Section TI - Chapter 19. Carcinoid Tumors A1 - Pitt, Susan C. A1 - Chen, Herbert A2 - Morita, Shane Y. A2 - Dackiw, Alan P. B. A2 - Zeiger, Martha A. PY - 2010 T2 - McGraw-Hill Manual: Endocrine Surgery AB - Carcinoid tumors were first described in a 1907 paper titled "Karzinoide Tumoren des Dünndarms," or "Cancer-like Tumors of the Gut," by the German pathologist Siegfried Oberndorfer.1 He used the word karzinoide to illustrate the benign behavior of a tumor whose cells appeared malignant under the microscope.1 Later in 1914, Gosset and Masson characterized the endocrine-related properties of carcinoid tumors.2 Over the years, a considerable amount of confusion has developed over the definition of carcinoid tumors, largely because, historically, the name carcinoid was used in reference to all neuroendocrine tumors. In general, the term carcinoid refers to endocrine tumors of the gastrointestinal (GI) tract, bronchopulmonary epithelium, and rare other sites but not to pancreatic neuroendocrine tumors (PNETs), also called islet cell tumors. This chapter focuses on GI carcinoid tumors, which arise from enterochromaffin, enterochromaffin-like, or Kulchitsky cells that are part of the diffuse neuroendocrine cell types of the gut. These cells are distinguished by their ability to secrete bioactive peptides and amines, such as serotonin, somatostatin, gastrin, and histamine. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/28 UR - accesssurgery.mhmedical.com/content.aspx?aid=6163770 ER -