TY - CHAP M1 - Book, Section TI - Chapter 104. Lymphedema A1 - Norton, Steve A2 - Kuerer, Henry M. PY - 2010 T2 - Kuerer's Breast Surgical Oncology AB - Lymphedema is caused when protein-rich fluid accumulates in the interstitium due to impaired function of lymphatic tissues. Proteins and other macromolecular wastes with water constitute lymphatic functional loads; these wastes rely upon specially structured absorptive and transport structures in regional anatomy for their return to the central circulation. When lymph stasis prevails, inflammatory processes and fibrosis (lymphostatic fibrosis) trigger changes in tissue density, further entrapping superficial vessels and accelerating the mechanical insufficiency.1 SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/04/20 UR - accesssurgery.mhmedical.com/content.aspx?aid=6406997 ER -