TY - CHAP M1 - Book, Section TI - Chapter 8. Genetic Predisposition Syndromes A1 - Robinson, Linda A2 - Kuerer, Henry M. PY - 2010 T2 - Kuerer's Breast Surgical Oncology AB - In 1860, Dr. Broca, a French surgeon, reported on the pedigree of his wife's family because of her early-onset breast cancer and the striking family history of breast cancer.1 At around the same time, in 1865, Dr. Gregory Mendel was looking at the genetics of garden peas; his work would lay the foundation for the field of genetics. In the last 150 years, the identification and recognition of the molecular genetics component of disease has advanced, and the area of breast cancer has been no exception. Molecular genetic testing is redefining familial cancer and will continue to do so for many years. This chapter will review the clinical features, causative genes, and medical management options for hereditary breast cancer syndromes. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/29 UR - accesssurgery.mhmedical.com/content.aspx?aid=6406141 ER -