TY - CHAP M1 - Book, Section TI - Machine Preservation of Liver Grafts A1 - Goldaracena, Nicolas A1 - Chun, Yi-Min A1 - Selzner, Markus A2 - Molmenti, Ernesto Pompeo A2 - Santibañes, Martin de A2 - Santibañes, Eduardo de PY - 2021 T2 - Liver Transplantation: Operative Techniques and Medical Management AB - Liver transplantation is the only treatment option for patients with end-stage liver disease. However, the number of waiting list candidates exceeds by far the number of available grafts. Therefore, the use of marginal grafts has emerged as a very useful tool to increase the donor pool. These extended-criteria organs include grafts donated after circulatory death (DCD), steatotic livers, livers from elderly donors, and grafts with prolonged cold storage time. Unfortunately, extended-criteria grafts are more susceptible to ischemic injury during cold static storage and are more likely to develop graft dysfunction and biliary complications after transplantation.1 In addition, cold static storage does not allow the assessment of organs during the preservation period and moreover does not allow the application of protective strategies. Currently, the decision to accept or decline a liver graft is mainly based on personal opinion rather than objective data. The shortcomings of cold static storage and advances in perfusion technology have resulted in an increased interest in normothermic perfused organ preservation as an alternative to cold static storage.1–3 SN - PB - McGraw Hill CY - New York, NY Y2 - 2024/03/29 UR - accesssurgery.mhmedical.com/content.aspx?aid=1180112341 ER -