TY - CHAP M1 - Book, Section TI - Postinjury Inflammation and Organ Dysfunction A1 - Moran, Benjamin A1 - Tisherman, Samuel A. A2 - Feliciano, David V. A2 - Mattox, Kenneth L. A2 - Moore, Ernest E. PY - 2020 T2 - Trauma, 9e AB - KEY POINTSMultiple organ failure (MOF) is defined as dysfunction of greater than one organ system.Although multiple scoring systems of MOF exist (Marshall, Sequential Organ Failure Assessment, Denver), there is no gold standard.MOF accounts for approximately 50% of delayed deaths in trauma.The pulmonary, cardiac, and renal systems are affected first, usually within 3 days, followed later by derangements in hepatic function (>3 days).Fifty percent of MOF mortality occurs within 3 days, with 80% of mortality occurring within 7 days.Traumatic injury and resuscitation from hemorrhagic shock result in proinflammatory and anti-inflammatory responses, which affect multiple organ systems and can contribute to sequential organ dysfunction.Prevention of MOF is directed at early resuscitation, avoidance of hypotension, protective lung ventilation, renal protection, and prevention of secondary infection. SN - PB - McGraw Hill CY - New York, NY Y2 - 2024/03/28 UR - accesssurgery.mhmedical.com/content.aspx?aid=1175137452 ER -