TY  - CHAP
M1  - Book, Section
TI  - Head and Neck Manifestations of HIV
A1  - Chan, Yvonne
A1  - Goddard, John C.
PY  - 2019
T2  - K.J. Lee’s Essential Otolaryngology: Head and Neck Surgery, 12e
AB  - Human  immunodeficiency  virus  (HIV)  is  a  blood-borne  and  sexually  transmitted  infection  that  leads  to  acquired  immunodeficiency  syndrome  (AIDS).HIV  belongs  to  the  Lentivirus  genus  of  the  retroviridae  family.An  enveloped,  single-stranded  RNA  virus  that  primarily  infects  CD4+  T  lymphocytes  (though  it  can  infect  other  cell  that  express  CD4,  such  as  macrophages).Viral  life  cycleInfection  of  the  host  cell  via  binding  to  CD4  and  fusion  of  the  viral  envelope  and  cell  membrane.The  viral  RNA  is  reverse  transcribed  in  DNA  and  integrated  into  the  host  genome.There  is  a  period  of  latency,  followed  by  an  active  viral  replication  phase.New  viral  particles  “bud  off”  of  the  cell  membrane  of  the  infected  cell.This  eventually  results  in  cellular  destruction  and  consequently  impairment  of  the  host’s  immune  system.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/19
UR  - accesssurgery.mhmedical.com/content.aspx?aid=1172368323
ER  -