TY - CHAP M1 - Book, Section TI - Trauma-Induced Coagulopathy A1 - Moore, Hunter B. A1 - Gonzalez, Eduardo A1 - Moore, Ernest E. A2 - Moore, Ernest E. A2 - Feliciano, David V. A2 - Mattox, Kenneth L. PY - 2017 T2 - Trauma, 8e AB - Despite advances in emergency medical systems (EMS) and trauma care, deaths from injury have increased in the United States over the last decade.1 In both the civilian2 and military3 settings, uncontrolled hemorrhage is the leading cause of preventable death after injury. In civilian studies, >95% of deaths from hemorrhage occur within the first 24 hours at a median time <3 hours.2 Consequently, there is intense interest worldwide in the pathogenesis of trauma induced coagulopathy (TIC), and its early management. While there have been substantial insights, the words of Mario Stefanini in his address to the New York Academy of Medicine in 19544 remain applicable today: SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accesssurgery.mhmedical.com/content.aspx?aid=1147414849 ER -